MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2) is a key component of the autophagy machinery that functions as a ubiquitin-like modifier in autophagosome formation and maturation 12. The protein plays essential roles in cellular homeostasis by facilitating the degradation and recycling of cytoplasmic components through autophagosome-dependent lysosomal pathways 3. MAP1LC3B2 expression serves as a marker for autophagy activation, with increased levels indicating enhanced autophagic flux 12. Mechanistically, MAP1LC3B2 is regulated through multiple signaling pathways, including cAMP-PKA-AMPK-SIRT1 signaling, and its expression can be epigenetically controlled by DNA methylation mediated by DNMT3A 13. The gene has significant disease relevance, as genetic mutations in MAP1LC3B2 predispose individuals to severe viral infections, including herpes encephalitis and enhanced susceptibility to varicella zoster virus 45. Clinically, MAP1LC3B2 upregulation has been observed in cancer treatment contexts, where it contributes to anti-inflammatory effects and apoptotic processes 67. Additionally, MAP1LC3B2 is subject to translational control in platelets through retinoic acid receptor-α binding, demonstrating its diverse regulatory mechanisms across different cell types 8.