SCTR (secretin receptor) is a G protein-coupled receptor activated by the hormone secretin, mediating diverse physiological processes through cAMP-dependent signaling pathways 1. The receptor regulates duodenal pH by inhibiting gastric acid secretion and stimulating pancreatic bicarbonate production, while also playing a central role in diet-induced thermogenesis by activating brown adipocyte lipolysis to promote satiation 1. SCTR modulates water homeostasis through renal water reabsorption regulation and contributes to synaptic plasticity in the central nervous system 1. Dysregulation of SCTR signaling is implicated in metabolic disease pathogenesis. Increased biliary SCTR expression in non-alcoholic fatty liver disease (NAFLD) promotes hepatic steatosis through miR-125b-mediated upregulation of lipogenesis genes 2. In biliary atresia, elevated liver SCTR expression correlates with worse prognosis following portoenterostomy, predicting lower native liver survival and reduced bilirubin clearance 3. Therapeutically, purmorphamine, a small-molecule SCTR modulator, enhances secretin-activated brown fat thermogenesis and reduces obesity in animal models by potentiating SCTR-cAMP-PKA signaling and lipolysis 4. SCTR also exhibits anti-inflammatory and anti-nociceptive potential in ocular tissues 5, suggesting broader therapeutic applications beyond metabolic regulation.