SEC14L5 (SEC14 like lipid binding 5) is a cytoplasmic protein with lipid-binding capacity involved in cellular stress responses and disease susceptibility. The gene encodes a P53-dependent target that produces both linear mRNA and circular RNA isoforms 1. Following ionizing radiation exposure, SEC14L5 circular transcripts show prolonged induction in brain tissue and neurons, with increased stability compared to linear counterparts, suggesting roles in radiation response and neurodevelopment 1. SEC14L5 has been identified as a significant molecular marker in multiple disease contexts. In post-traumatic stress disorder, SEC14L5 emerged as one of seven highly enriched genes in peripheral blood mononuclear cells from PTSD patients, with functional network analysis indicating its involvement in cell proliferation and DNA damage responses 2. The gene was also associated with outpatient surgeries in African-American carriers of the Val122Ile TTR mutation linked to cardiac amyloidosis, with differential methylation at CpG sites in SEC14L5 detected epigenome-wide 3. In prostate cancer, SEC14L5 was identified as part of a 12-gene prognostic model predictive of alkaliptosis resistance and biochemical recurrence-free survival 4. Additionally, a regulatory variant in the NAGPA locus modulates SEC14L5 expression and confers shared genetic risk for Kawasaki disease and IgA vasculitis 5. These findings suggest SEC14L5 functions in stress-response pathways with potential clinical relevance as a biomarker across neuropsychiatric, cardiac, and malignant disorders.