SEC22B is a SNARE protein that functions as a critical vesicle trafficking component mediating membrane fusion between the endoplasmic reticulum and Golgi apparatus 1. The protein plays essential roles in multiple cellular processes including conventional vesicle transport, secretory autophagy, and metabolic regulation. In secretory autophagy, SEC22B facilitates the fusion of autophagosomes with the plasma membrane, enabling the secretion of cytosolic proteins including inflammatory cytokines like IL6 2. SEC22B undergoes phosphorylation at serine 137 in response to glucagon signaling, serving as a key hepatic signaling node that regulates glycogen, lipid, and amino acid metabolism 3. The protein is also crucial for VLDL secretion, where its degradation via chaperone-mediated autophagy impairs hepatic lipid transport 4. During neuronal development, SEC22B forms non-fusogenic complexes with syntaxin-1 at ER-plasma membrane contacts and interacts with extended synaptotagmins to promote neurite growth and ramification 5. Dysregulation of SEC22B has clinical significance, as elevated expression correlates with colorectal cancer aggressiveness and metastasis, while knockdown reduces cancer cell survival under stress conditions 6.