VAMP7 (vesicle-associated membrane protein 7) is a key SNARE complex protein that mediates membrane fusion events across multiple cellular processes. VAMP7 functions as an essential component of SNARE complexes involved in autophagosome-lysosome fusion, with the STX17-SNAP47-VAMP7/VAMP8 complex serving as the default machinery for this process in both selective and bulk autophagy 1. The protein also mediates exosome secretion by forming a SNARE complex with syntaxin-4 and SNAP-23 to facilitate multivesicular body fusion with the plasma membrane 2. Additionally, VAMP7 participates in mitochondria-lysosome contacts under hypoxic conditions as part of the STX17-SNAP29-VAMP7 complex 3. In immune responses, basophil-specific VAMP7 regulates chrX|Y itch and skin barrier integrity in atopic dermatitis by maintaining basophil activity and controlling inflammatory mediator release 4. Clinically, increased VAMP7 gene dosage disrupts male urogenital development by enhancing estrogen receptor action, leading to masculinization disorders including hypospadias and cryptorchidism 5. VAMP7 gene copy number analysis serves as a reliable screening method for detecting sex chromosome X|Y in newborns 6. The protein shows therapeutic potential, as VAMP7 deletion significantly reduces tumor growth and metastasis in breast cancer models 2.