SNAP47 is a SNARE protein that mediates membrane fusion events critical for autophagy and exocytosis. As a member of the SNAP-25 protein family, it contains both Qb and Qc SNARE domains, enabling interaction with diverse partner SNAREs. SNAP47 functions as a key component of the STX17-SNAP47-VAMP7/VAMP8 SNARE complex, which mediates autophagosome-lysosome fusion in both selective autophagy under non-starvation conditions and starvation-induced bulk autophagy 1. Mechanistically, deacetylated SNAP47 recruits HOPS components to autophagic vacuoles, promoting SNARE complex assembly, while acetylation by CBP inhibits this process 2. SNAP47 also participates in exosome release by interacting with VAMP5 and syntaxins 3. Beyond autophagy, SNAP47 mediates postsynaptic AMPA-receptor insertion and facilitates viral capsid assembly during enterovirus infection 4. In disease contexts, reduced SNAP47 levels correlate with cognitive impairment and cognitive decline rates in Alzheimer's disease and Lewy body dementias 5. A circular RNA isoform of SNAP47 promotes chemoresistance in DDP-tolerant non-small-cell lung cancer cells via a miR-625-5p-WEE1 axis 6. Clinical investigations targeting SNAP47-mediated autophagy pathways or modulating SNAP47 acetylation status may offer therapeutic approaches in neurodegenerative diseases and cancer resistance mechanisms.