SELPLG (selectin P ligand), located on chromosome 12, encodes P-selectin glycoprotein ligand-1, a cell surface receptor primarily involved in leukocyte adhesion and recruitment 1. The protein functions as a receptor for P-selectin on endothelial cells and platelets, mediating leukocyte tethering, rolling, and adhesive activation during inflammation 2. Additionally, SELPLG serves as a receptor for enterovirus 71 (EV71), and while SELPLG polymorphisms do not significantly correlate with EV71 infection severity, other genetic factors modulate disease outcome 3. In cardiovascular disease, SELPLG genetic variation influences cell surface protein expression levels without directly affecting coronary artery disease risk 42. SELPLG plays an emerging role in immune cell communication during Kawasaki disease vasculitis, where it functions as a crucial signal transduction gene among CD14+ monocytes 5. In osteosarcoma, reduced SELPLG expression correlates with increased metastatic potential and poor prognosis, with mechanisms involving long non-coding RNA regulation of cell proliferation and invasion pathways 67. SELPLG genetic variation has been investigated in multiple sclerosis pathogenesis, though associations remain inconclusive 8. Overall, SELPLG functions critically in immune cell recruitment and inflammatory processes with disease-specific roles in infection, malignancy, and vasculitis.