SEMA4G (semaphorin 4G) functions as a cell surface receptor that binds to PLXNB2 (plexin-B2) and plays a critical role in axon guidance during neural development 1. The gene is expressed early in embryonic development within the brain, spinal cord, and sensory organs, particularly in projection neuron populations, consistent with its role in neural pathway formation 2. SEMA4G participates in the semaphorin-plexin signaling pathway, which regulates cellular processes including neural crest cell migration, chemotaxis, and axon guidance 1. Beyond its developmental functions, SEMA4G demonstrates clinical significance in multiple disease contexts. Genetic variants, particularly rs4919510, are associated with cancer susceptibility in a tissue-specific manner, with differential expression patterns observed across tumor types - decreased expression in colorectal and lung cancers but increased expression in gastric cancer tissues 3. The gene also shows associations with thyroid carcinoma susceptibility and glaucoma medication non-adherence 45. Additionally, SEMA4G expression is dysregulated in schizophrenia across multiple brain regions, contributing to extracellular matrix pathway disruptions that may underlie cognitive impairment 6. In colorectal cancer liver metastasis, SEMA4G serves as a hepatocyte-specific ligand for PLXNB2, facilitating cancer cell adhesion and colonization 7.