SFRP5 (secreted frizzled-related protein 5) is a soluble antagonist of Wnt signaling pathways that functions as an anti-inflammatory adipokine with protective roles in metabolic and cardiovascular diseases 12. The protein directly binds to Wnt proteins, particularly Wnt5a, to negatively regulate both canonical and non-canonical Wnt signaling pathways 34. SFRP5 exerts anti-inflammatory effects by suppressing the JNK/TLR9 pathway in macrophages, thereby reducing inflammation and macrophage infiltration 2. In disease contexts, SFRP5 levels are significantly reduced in obesity, coronary artery disease, polycystic ovary syndrome, and atherosclerosis 356. Lower SFRP5 expression correlates with increased cardiovascular risk, unstable atherosclerotic plaques, and metabolic dysfunction 23. The protein's protective effects include amelioration of atherosclerosis progression, improvement of plaque stability, and reduction of chr10 low-grade inflammation associated with metabolic disorders 27. SFRP5 represents a promising therapeutic target and biomarker for obesity-related metabolic complications and cardiovascular diseases 41.