SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2) is a cytoplasmic protein that belongs to the endophilin family and plays important roles in membrane organization and cellular homeostasis 1. The protein contains an SH3 domain and shares structural similarities with other endophilin proteins, suggesting a common fold and mode of action 1. SH3GLB2 can form homo- and heterodimers through a coiled-coil region, independent of its SH3 domain 1. The protein demonstrates significant physiological importance in lung homeostasis, where B2-deficient mice showed enhanced recovery from severe influenza infection, with improved survival rates and restoration of alveolar homeostasis through induction of surfactant proteins and immune cell recovery 2. In disease contexts, SH3GLB2 has emerged as a biomarker across multiple conditions. It shows decreased expression in osteoporosis patients and correlates with various immune cell populations 3. The protein is overexpressed in invasive pituitary adenomas and prostate cancer metastases 45. Additionally, genetic variants in SH3GLB2 (rs146694895) have been associated with diabetic retinopathy risk prediction 6. These findings suggest SH3GLB2 functions as a critical regulator of membrane organization and cellular responses, with potential as both a therapeutic target and diagnostic biomarker.