FNBP1 is a cytoskeletal adaptor protein that coordinates actin dynamics with membrane trafficking and organellar homeostasis. Mechanistically, FNBP1 binds directly to Daam1 and participates in non-canonical Wnt signaling to regulate actin cytoskeletal reorganization during vertebrate gastrulation 1. The protein recruits N-WASP to enhance actin polymerization and promotes membrane invagination during clathrin-mediated endocytosis through lipid binding 1. Additionally, FNBP1 functions as a neuronal Golgiphagy receptor, sensing nutrient stress through its membrane tension-sensing properties and recruiting fragmented Golgi membranes to autophagosomes via LC3B interaction 2. Clinically, elevated FNBP1 expression correlates with poor prognosis across multiple malignancies. In glioblastoma, FNBP1 is upregulated through RBM15B-mediated m6A methylation and IGF2BP2-enhanced mRNA stability, promoting tumor progression by activating Smad3-mediated glycolysis 3. FNBP1 knockdown suppressed tumor growth and metastasis in glioblastoma models 3. Genome-wide association studies implicate FNBP1 as a biomarker for colorectal cancer prognosis 4 and identify it as a potential risk gene in amyotrophic lateral sclerosis and self-limited delayed puberty 5, 6. These findings establish FNBP1 as a multifunctional scaffold protein linking developmental signaling, cellular stress responses, and disease pathogenesis.