SINHCAF (SIN3-HDAC complex associated factor), also known as FAM60A, is a core subunit of the Sin3/HDAC chr12-remodeling complex with multifaceted roles in cell cycle regulation and transcriptional repression. In embryonic stem cells, SINHCAF stabilizes SIN3A on chr12 and maintains rapid proliferation with shortened G1-phase, preventing premature differentiation 1. The protein specifically represses HIF-2α expression through interaction with transcription factor SP1 and HDAC1 recruitment to target promoters, regulating hypoxia-responsive cellular functions including angiogenesis and viability 2. Clinically, SINHCAF is frequently amplified and overexpressed in malignant germ cell tumors (GCTs), where it promotes anchorage-dependent proliferation, tumorigenesis, and cell migration while suppressing differentiation-associated gene expression 1. SINHCAF overexpression also promotes osteosarcoma and cisplatin-resistant lung cancer development, with knockdown inhibiting proliferation and cell cycle progression 34. In esophageal adenocarcinoma, elevated SINHCAF predicts poor survival outcomes 5. A genetic variant in FAM60A (rs147538848) associates with type 2 diabetes susceptibility 6. Given its role in HDAC complex function, histone deacetylase inhibitors represent a promising therapeutic approach for SINHCAF-driven malignancies, particularly GCTs 7.