SLC16A14 encodes a proton-linked monocarboxylate transporter belonging to the solute carrier family 16, responsible for transporting monocarboxylates across the plasma membrane 1. Phylogenetic analysis suggests SLC16A14 most closely relates to aromatic amino acid and thyroid hormone transporters, consistent with a potential role in aromatic amino acid transport 1. The transporter is highly expressed in mouse kidney and central nervous system, with exclusive neuronal soma localization in the brain 1. SLC16A14 expression associates with diverse pathophysiological conditions. In severe dengue disease progression, SLC16A14 upregulation in peripheral blood mononuclear cells correlates with neutrophil-mediated immunity and inflammatory responses 2. In epithelial ovarian cancer, SLC16A14 expression significantly associates with progression-free survival, suggesting prognostic value 3. During drug resistance development in ovarian cancer cell lines, SLC16A14 expression is altered, indicating potential involvement in chemoresistance mechanisms 45. Following ozone exposure, SLC16A14 is regulated through an lncRNA-miRNA-mRNA network axis (NEAT1/hsa-miR-6835-3p/SLC16A14), linking it to inflammatory responses and oxidative stress 6. In heat tolerance studies, SLC16A14 is identified as a candidate gene associated with thermal resistance in oysters 7. A genetic variant near SLC16A14 shows suggestive association with obsessive-compulsive disorder severity 8.