SLC24A3 encodes a calcium, potassium:sodium antiporter that transports 1 Ca²⁺ and 1 K⁺ in exchange for 4 Na⁺, functioning as a critical regulator of intracellular calcium homeostasis. The protein is localized to the plasma membrane and plays important roles in calcium ion transmembrane transport and bone mineralization. Recent genomic studies have identified SLC24A3 as a significant risk locus for cardiovascular diseases, particularly fibromuscular dysplasia, where it contributes to mechanisms involving actin cytoskeleton and vascular contraction 1. The gene has also emerged as a key locus in migraine susceptibility, with enhanced genetic signals detected in migraine-first patients 2. In cancer contexts, SLC24A3 demonstrates tumor suppressor properties, with low expression associated with poor prognosis in cervical cancer 3 and serving as a prognostic biomarker in multiple cancer types including colon adenocarcinoma 4, triple-negative breast cancer 5, and cervical cancer 6. Additionally, variants near SLC24A3 at chr20 region 20p11 are associated with body fat mass regulation 7. The gene's involvement in calcium homeostasis appears central to its diverse pathological roles across cardiovascular, neurological, and oncological conditions.