SLC24A2 encodes a calcium-potassium:sodium antiporter that exchanges 1 Ca²⁺ and 1 K⁺ for 4 Na⁺ across the plasma membrane 12. This transporter is essential for regulating intracellular calcium homeostasis and plays critical roles in neuronal function, including long-term synaptic plasticity and photoreceptor responses in the retina 3. SLC24A2 is expressed in islet β cells and influences ribosome biogenesis 4, linking metabolic dysfunction to cancer risk pathways. SLC24A2 variants have been associated with multiple diseases. In Takayasu arteritis, a genetic locus in SLC24A2 (rs2891138) showed the most significant association with disease angiographic patterns 5. SLC24A2 mutations have been identified in pancreatic ductal adenocarcinoma, with an E287D substitution reducing protein stability and potentially contributing to disease pathogenesis 6. Elevated plasma peptide levels of SLC24A2 phosphopeptides were observed in Alzheimer's disease patients compared to controls 7. Additionally, SLC24A2 genetic variants correlate with complicating cardiac diseases in scrub typhus infection 8. In cancer biology, abnormal SLC24A2 expression occurs in 17 cancer types and significantly affects prognosis in colon adenocarcinoma 9. SLC24A2 also influences skin pigmentation across East Asian populations 10.