SLC25A30 (also known as UCP6/KMCP1) is a mitochondrial inner membrane antiporter primarily functioning in inorganic anion transport 1. It catalyzes counter-exchange transport of sulfate, sulfite, thiosulfate, and phosphate, with highest transport affinity for sulfate and thiosulfate 1. The protein also transports dicarboxylates (malonate, malate, citramalate) and aspartate at lower efficiency, along with very low unidirectional uniport activity 1. A major proposed physiological role is exporting sulfite and thiosulfate—hydrogen sulfide degradation products—from mitochondria, thereby regulating H2S signaling levels 1. Beyond its canonical transport function, SLC25A30 demonstrates disease relevance in esophageal adenocarcinoma (EAC), where it exhibits post-transcriptional upregulation at the protein level despite normal mRNA abundance, suggesting selective cancer-specific regulatory mechanisms 2. In lipid metabolism, SLC25A30 was identified among key genes involved in fatty acid composition and adipogenesis in sheep liver, implicating it in metabolic regulation beyond anion transport 3. These findings indicate SLC25A30 serves dual roles in mitochondrial sulfur metabolism and metabolic regulation with potential involvement in disease pathogenesis.