SLC26A11 is a multifunctional anion transporter that operates as both an anion exchanger and chloride channel across various tissues. The protein mediates sodium-independent sulfate transport and may cooperate with SLC26A2 to facilitate DIDS-sensitive sulfate uptake in high endothelial venules endothelial cells 1. In the central nervous system, SLC26A11 is abundantly expressed in Purkinje cells of the cerebellum and functions as a voltage-gated chloride channel activated upon neuronal depolarization to membrane potentials below -20 mV 2 3. The protein plays a critical role in neuronal volume regulation, as chloride entry via SLC26A11 following sodium influx leads to cytotoxic neuronal swelling and cell death during brain injury 3. Additionally, SLC26A11 stimulates vacuolar H+-ATPase activity, suggesting involvement in cellular acid-base regulation 2. The gene is expressed in kidney, brain, and placenta, with potential roles in renal physiology that remain to be fully characterized 1 4. Clinically, SLC26A11 has been identified in gene fusions associated with chr17 myeloid leukemia and sarcomas, though the functional significance of these alterations requires further investigation 5 6.