SLC26A8 is a testis-specific anion transporter that mediates sulfate and oxalate exchange against chloride ions across cell membranes 12. It functions as a regulatory partner of the cystic fibrosis transmembrane conductance regulator (CFTR), stimulating CFTR anion transport activity and cooperating in chloride and bicarbonate ion flux regulation 345. SLC26A8 localizes to the sperm annulus and plays a critical role in sperm flagellar structure and motility 67. Loss-of-function mutations in SLC26A8 cause male infertility characterized by severe asthenozoospermia with structural defects including absence of the mitochondrial sheath and annulus 8. However, heterozygous mutations alone appear insufficient to cause infertility in males 9, suggesting recessive inheritance patterns 8. Notably, SLC26A8 variants were identified in rosacea families and associated with neurogenic inflammation through altered vasoactive neuropeptide production 10, indicating pleiotropic functions beyond reproduction. Clinically, SLC26A8 mutations are recognized causes of spermatogenic failure, though the specific prevalence among infertile men remains unclear 11.