SLC25A41 encodes SCaMC-3-like (SCaMC-3L), a calcium-independent mitochondrial ATP-Mg/Pi exchanger that catalyzes electroneutral exchange of Mg-ATP or free ADP against inorganic phosphate across the inner mitochondrial membrane 1. Unlike longer SCaMC paralogues that contain calcium-binding EF-hand domains, SLC25A41 represents a truncated variant lacking the N-terminal calcium-binding extension, indicating functional specialization following a partial duplication event in early mammalian evolution 1. The protein displays a restricted tissue expression pattern, with preferential expression in testis and lower levels in brain 12. SLC25A41 participates in adenine nucleotide transport via a novel calcium-independent mechanism distinct from classical ADP/ATP translocases 1. As a member of the SLC25 family of mitochondrial solute carriers, it contributes to the broader repertoire of mitochondrial transport proteins found throughout mammalian genomes 3. Notably, SLC25A41 is not essential for male fertility when individually disrupted in mice, suggesting functional redundancy or non-critical roles in reproductive physiology 4. The calcium-independent ATP-Mg/Pi exchange function supports mitochondrial energy metabolism and nucleotide homeostasis.