SLC27A2 (FATP2) is a membrane-bound fatty acid transport protein that facilitates cellular uptake of long-chain fatty acids (LCFAs) and exhibits acyl-CoA synthetase activity for fatty acid activation 1. The protein is localized to peroxisomal membranes where it participates in fatty acid oxidation pathways essential for cellular energy metabolism 12. SLC27A2 plays critical roles in hepatocyte nuclear factor 4 (HNF4)-regulated fatty acid oxidation required for intestinal stem cell renewal 2. In cancer contexts, SLC27A2 functions as a tumor suppressor in hepatocellular carcinoma, where its downregulation under hypoxic conditions reduces LCFA uptake, preventing lipid peroxidation-induced cytotoxicity while promoting tumor survival and immune evasion through redistribution of fatty acids to tumor-associated macrophages 3. The protein also serves as a biomarker of lipid peroxidation in inflammatory conditions, being upregulated in nasal polyp epithelial cells in response to type 2 inflammation 4. Additionally, SLC27A2 functions as a partner of mitofusin 2 (MFN2) in autophagy regulation and interorganelle communication 5. Therapeutically, SLC27A2 inhibition shows context-dependent effects, demonstrating anti-inflammatory properties in monocytes but pro-inflammatory effects in mature macrophages 6, and serves as a target for novel cancer therapeutics 7.