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GeneE
2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SLC35G4
solute carrier family 35 member G4
Chromosome 18 · 18p11.21
NCBI Gene: 646000Ensembl: ENSG00000236396.8HGNC: HGNC:31043UniProt: P0C7Q5
3PubMed Papers
16Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
choline transmembrane transporter activitycholine transportmembranespondylolisthesissuntanrespiratory system diseaseAbruptio Placentae
✦AI Summary

Based on limited published evidence, SLC35G4 encodes a choline transmembrane transporter with demonstrated organic cation transport activity. Functional characterization shows SLC35G4 exhibits choline transporter activity with a KM value of approximately 12-50 µM, aligning with physiological plasma choline concentrations 1. The transporter is inhibited by hemicholinium-3, decynium-22, and verapamil, suggesting involvement in cholinergic neurotransmission regulation 1. SLC35G4 also transports additional organic cations beyond choline 2, indicating polyspecific substrate recognition. Its biological role in acetylcholine biosynthesis and other choline-dependent processes remains to be fully characterized.

Sources cited
1
SLC35G4 demonstrated significantly increased choline uptake and transport of organic cations
PMID: 39098524
2
SLC35G4 exhibits KM value for choline of 12-50 µM and is inhibited by hemicholinium-3, decynium-22, and verapamil
PMID: 40972734
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ16
spondylolisthesisOpen Targets
0.30Weak
suntanOpen Targets
0.20Weak
respiratory system diseaseOpen Targets
0.20Weak
Abruptio PlacentaeOpen Targets
0.19Weak
placenta praeviaOpen Targets
0.18Weak
hypertrophic cardiomyopathyOpen Targets
0.18Weak
placental retentionOpen Targets
0.15Weak
preeclampsiaOpen Targets
0.15Weak
facial painOpen Targets
0.05Suggestive
Subdural hemorrhageOpen Targets
0.03Suggestive
sinusitisOpen Targets
0.02Suggestive
circadian rhythm sleep disorderOpen Targets
0.02Suggestive
osteitis deformansOpen Targets
0.02Suggestive
schizophreniaOpen Targets
0.02Suggestive
craniofacial microsomiaOpen Targets
0.00Suggestive
hearing lossOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
SLC35F2Shared pathway100%SLC35F5Shared pathway100%SLC35F3Shared pathway100%SLC35F4Shared pathway100%SLC25A48Shared pathway50%FLVCR2Shared pathway50%
Tissue Expression6 tissues
Lung
0%
Bone Marrow
0%
Heart
0%
Ovary
0%
Liver
0%
Brain
0%
Gene Interaction Network
Click a node to explore
SLC35G4SLC35F2SLC35F5SLC35F3SLC35F4SLC25A48FLVCR2
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt P0C7Q5
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.31LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.81 [0.52–1.31]
RankingsWhere SLC35G4 stands among ~20K protein-coding genes
  • #19,018of 20,598
    Most Researched3
  • #13,783of 17,882
    Most Constrained (LOEUF)1.31
Genes detectedSLC35G4
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters.
PMID: 39098524
J Biol Chem · 2024
1.00
2
Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity.
PMID: 40972734
Biochem Pharmacol · 2025
0.50