SLC38A6 (solute carrier family 38 member 6) encodes sodium-coupled neutral amino acid transporter 6 (SNAT6), functioning primarily as an amino acid transporter with selectivity for L-glutamine, L-glutamate, and L-arginine 1. The transporter facilitates amino acid uptake across the plasma membrane, playing a central role in glutamine metabolism and mitochondrial respiration 2. Mechanistically, SLC38A6 expression is regulated by EP300-mediated histone modifications at its promoter 2. Loss-of-function variants impair amino acid uptake; homozygous deletion in mice causes reduced L-arginine uptake in cerebellar neurons, decreased Purkinje cell excitability, and elevated ferroptosis markers 1. Clinically, SLC38A6 variants contribute approximately 8.35% of essential tremor cases, an autosomal dominant neurological disorder characterized by 4-12 Hz kinetic tremors 1. In cancer contexts, elevated SLC38A6 expression associates with poor prognosis in hepatocellular carcinoma and predicts 5-fluorouracil resistance in colorectal cancer 34. SLC38A6 overexpression promotes cancer cell proliferation, glutamine metabolism, and mitochondrial respiration 2, while upregulation in gastric cancer occurs via the circ_0110940/miR-1178-3p regulatory axis 5. SLC38A6 is also implicated as an M2 macrophage marker associated with immunosuppression in gastric cancer 6.