SLC39A11 (ZIP11) is a metal transporter primarily involved in zinc homeostasis, with emerging roles in manganese transport and cellular aging processes. The protein regulates cytosolic zinc concentrations through transport from extracellular compartments or intracellular organelles, with predominant localization in the nucleus and Golgi apparatus 1. SLC39A11 exhibits tissue-specific regulation, being highly expressed in stomach and colon where it responds to dietary zinc availability and helps maintain mucosal integrity 1. Recent studies have identified SLC39A11 as a longevity-associated gene, with mutations causing accelerated aging phenotypes in zebrafish through cellular senescence pathways 2. Notably, SLC39A11 functions as a manganese transporter, protecting against aging by regulating cellular manganese homeostasis and preventing manganese accumulation 2. The gene shows clinical relevance across multiple diseases: genetic variants associate with neurodegeneration biomarkers 3, inflammatory bowel disease through calprotectin regulation 4, male fertility via seminal zinc levels 5, and breast cancer prognosis 67. Single nucleotide polymorphisms in SLC39A11 significantly affect its transport function and cellular phenotypes including proliferation and migration 8, highlighting its importance in disease susceptibility and progression.