HomeAboutRankingsData Sources
Β© 2026 GeneE
🧬
GeneE
10 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
SLC39A7
solute carrier family 39 member 7
Chromosome 6 Β· 6p21.32
NCBI Gene: 7922Ensembl: ENSG00000112473.20HGNC: HGNC:4927UniProt: A0A024RCX7
93PubMed Papers
1Diseases
0Drugs
6Pathogenic Variants
FUNCTIONAL ROLE
Transporter
CLINICAL
OMIM Disease Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
zinc ion transmembrane transporter activityprotein bindingintracellular zinc ion homeostasisB cell differentiationAgammaglobulinemia 9, autosomal recessive
✦AI Summary

SLC39A7 (ZIP7) is a zinc transporter localized to the endoplasmic reticulum (ER) and Golgi apparatus that mediates zinc release from intracellular stores to the cytosol, serving as a critical regulator of cytosolic zinc homeostasis 12. The protein requires post-translational phosphorylation for activation and subsequently activates downstream pathways promoting cell growth and proliferation 34. SLC39A7 functions as a rate-limiting factor in endoplasmic reticulum-associated protein degradation (ERAD) by enhancing Rpn11-mediated deubiquitination of misfolded proteins, with therapeutic potential in neurodegenerative diseases 5. The protein plays essential roles in B cell development and receptor signaling 6, and maintains mitochondrial zinc homeostasis through formation of NLRX1-SLC39A7 complexes that regulate mitochondrial dynamics and mitophagy 78. SLC39A7 mediates zinc-induced ferroptosis and protects against ER stress 910. Disease relevance includes agammaglobulinemia 9 (autosomal recessive) and contributions to intervertebral disc degeneration, colorectal cancer proliferation (via Akt/mTOR signaling), gastric cancer progression (regulated by miR-139-5p), systemic sclerosis-associated skin fibrosis, and hepatotoxicity under PFOS exposure 11121314. Additionally, METTL9-mediated methylation of SLC39A7 suppresses ferroptosis and regulates mesenchymal stem cell adipogenesis, with implications for osteoporosis 15.

Sources cited
1
SLC39A7 functions as a rate-limiting factor in endoplasmic reticulum-associated protein degradation (ERAD) by enhancing Rpn11-mediated deubiquitination of misfolded proteins, with therapeutic potential in neurodegenerative diseases .
PMID: 38670102
2
The protein plays essential roles in B cell development and receptor signaling , and maintains mitochondrial zinc homeostasis through formation of NLRX1-SLC39A7 complexes that regulate mitochondrial dynamics and mitophagy , .
PMID: 30718914
3
Additionally, METTL9-mediated methylation of SLC39A7 suppresses ferroptosis and regulates mesenchymal stem cell adipogenesis, with implications for osteoporosis .
PMID: 40414869
⚠Limited data available β€” This gene has 3 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜1
Agammaglobulinemia 9, autosomal recessiveUniProt
Pathogenic Variants6
NM_006979.3(SLC39A7):c.1114C>T (p.Gln372Ter)Likely pathogenic
Agammaglobulinemia 9, autosomal recessive|not provided
β˜…β˜†β˜†β˜†2025β†’ Residue 372
NM_006979.3(SLC39A7):c.650T>C (p.Leu217Pro)Pathogenic
Agammaglobulinemia 9, autosomal recessive|not provided
β˜…β˜†β˜†β˜†2025β†’ Residue 217
NM_006979.3(SLC39A7):c.568C>G (p.Pro190Ala)Pathogenic
not provided|Agammaglobulinemia 9, autosomal recessive
β˜…β˜†β˜†β˜†2025β†’ Residue 190
NM_006979.3(SLC39A7):c.868C>T (p.Arg290Ter)Likely pathogenic
Agammaglobulinemia 9, autosomal recessive
β˜…β˜†β˜†β˜†2024β†’ Residue 290
NM_006979.3(SLC39A7):c.53G>A (p.Trp18Ter)Likely pathogenic
not provided
β˜…β˜†β˜†β˜†2019β†’ Residue 18
NM_006979.3(SLC39A7):c.1087G>A (p.Glu363Lys)Pathogenic
Agammaglobulinemia 9, autosomal recessive
β˜†β˜†β˜†β˜†2022β†’ Residue 363
View on ClinVar β†—
Related Genes
COL11A2Protein interaction94%KIFC1Protein interaction94%SLC30A6Protein interaction89%DSEProtein interaction88%PFDN6Protein interaction88%STUB1Protein interaction87%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
SLC39A7COL11A2KIFC1SLC30A6DSEPFDN6STUB1
PROTEIN STRUCTURE
Preparing viewer…
PDB8GZE Β· 3.40 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.84LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.60 [0.43–0.84]
RankingsWhere SLC39A7 stands among ~20K protein-coding genes
  • #5,165of 20,598
    Most Researched93
  • #3,348of 5,498
    Most Pathogenic Variants6
  • #7,168of 17,882
    Most Constrained (LOEUF)0.84
Genes detectedSLC39A7
Sources retrieved10 papers
Response timeβ€”
πŸ“„ Sources
10β–Ό
1
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn
PMID: 37876250
Autophagy Β· 2024
1.00
2
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
PMID: 28981607
Acta Biochim Biophys Sin (Shanghai) Β· 2017
0.90
3
METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells.
PMID: 40414869
Mol Med Β· 2025
0.80
4
ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure.
PMID: 39579909
Sci Total Environ Β· 2024
0.70
5
The Zn
PMID: 38670102
Dev Cell Β· 2024
0.60