SLC41A2 is a plasma-membrane magnesium transporter that mediates voltage-dependent Mg2+ uptake across cell membranes 1. The protein functions as an 11-transmembrane spanning transporter with an N-terminus-outside/C-terminus-inside topology 1. Beyond magnesium, SLC41A2 transports other divalent metal cations with selectivity: Ba2+ > Ni2+ > Co2+ > Fe2+ > Mn2+, but notably not Ca2+, Zn2+, or Cu2+ 2. Unlike its homolog SLC41A1, SLC41A2 expression is not regulated by extracellular magnesium levels 2. SLC41A2 may mediate magnesium fluxes across both plasma and organellar membranes 3. Clinically, genetic variation in SLC41A2 influences diabetes and prediabetes risk through modulation of serum magnesium levels, with this effect mediated partly through insulin resistance 4. Additionally, SLC41A2 expression associates with cellular susceptibility to paclitaxel chemotherapy, with knockdown studies demonstrating increased drug sensitivity 5. SLC41A2 has been identified as a target of microRNAs dysregulated in hepatitis B virus-induced hepatocellular carcinoma 6, though the functional significance remains to be elucidated.