SNAPC2 is a core subunit of the snRNA Activating Protein Complex (SNAPc), which directs transcription initiation of both RNA polymerase II and III small nuclear RNA (snRNA) genes 1. As part of SNAPc, SNAPC2 binds to the proximal sequence element (PSE), a conserved promoter element upstream of snRNA genes, and recruits basal transcription factors including TBP and BRF2 to facilitate pre-initiation complex assembly 1. Structurally, SNAPC2 localizes near promoter DNA within the transcription complex 1. Beyond its canonical role in snRNA transcription, SNAPC2 has emerged as a significant disease biomarker. In hepatocellular carcinoma, SNAPC2 is upregulated and promotes tumor progression through increased cell proliferation and migration; reducing SNAPC2 expression decreases cancer cell growth and induces apoptosis 2. In glioblastoma, SNAPC2 hypermethylation serves as an epigenetic biomarker associated with altered prognosis 3. Additionally, genetic variants in SNAPC2 show population-specific association with panic disorder risk 4, suggesting broader roles in neural function. These findings indicate SNAPC2 functions both as a fundamental transcriptional regulator and as a potential therapeutic target in malignancy.