SNRPN (small nuclear ribonucleoprotein polypeptide N) encodes the SmN protein, which functions as a component of the spliceosome machinery involved in pre-mRNA splicing 1. The protein is highly expressed in brain tissue and plays critical roles in neural development, regulating neurite outgrowth, neuron migration, and dendritic spine distribution 2. SNRPN functions through controlling the expression of Nr4a1, a nuclear receptor essential for neural development, with proper SNRPN levels being critical for cortical neurodevelopment 2. The gene exhibits genomic imprinting, being expressed exclusively from the paternal allele through differential DNA methylation patterns established during gametogenesis 31. SNRPN is located in the Prader-Willi syndrome (PWS) critical region on chromosome 15-q13, and its loss contributes to PWS pathogenesis 34. The maternal allele remains epigenetically silenced but can be reactivated through targeted epigenome editing approaches 4. SNRPN methylation patterns serve as reliable diagnostic markers for PWS and related chromosome 15 imprinting disorders, with methylation levels increasing with age 56. Dysregulation of SNRPN is associated with neurodevelopmental disabilities including autism spectrum disorders 2.