Based on limited published evidence, SNRNP48 is a component of the U11 small nuclear ribonucleoprotein particle involved in U12-type spliceosomal function. SNRNP48 is positioned near the 5' end of U11 snRNA and stabilizes binding of incoming U12-type 5' splice sites through base-pairing and non-canonical base-triple interactions with U11 snRNA stem-loop 3 1. The protein functions in mRNA splicing via the spliceosome and spliceosomal conformational changes. SNRNP48 was identified as a prognostically relevant biomarker in conjunctival melanoma transcriptome analysis 2.