SNRNP35 is a structural component of the U11/U12 minor spliceosome that catalyzes splicing of U12-dependent introns in eukaryotic pre-mRNAs. 1 The protein specifically recognizes and stabilizes U11 small nuclear RNA, working in concert with SNRNP25 and other minor spliceosome factors to enable 5' splice site recognition through base-pairing and non-canonical base-triple interactions with U11 snRNA stem-loop 3. 1 Beyond its canonical splicing function, SNRNP35 exhibits clinical relevance in stress-related and neoplastic contexts. Genetically regulated SNRNP35 expression in the dorsolateral prefrontal cortex is associated with post-traumatic stress disorder (PTSD) risk in military cohorts, with glucocorticoid stress hormones downregulating prefrontal SNRNP35 expression. 2 Functional validation confirms SNRNP35's role in U12-intron splicing, linking molecular dysfunction to neuropsychiatric pathology. 2 Additionally, SNRNP35 was identified as a candidate radiotherapy-resistance gene in lymphoma screening studies, suggesting potential involvement in cellular stress responses. 3 These findings indicate SNRNP35 functions as both a core spliceosomal component and a stress-responsive protein with implications for neuropsychiatric and oncological diseases.