PDCD7 (programmed cell death 7) is a structural component of the minor spliceosome that regulates U12-dependent intron splicing. Within the U11 small nuclear ribonucleoprotein complex, PDCD7 bridges SNRNP25 and SNRNP48, facilitating proper architecture and function of the 5' splice site recognition machinery 1. Beyond its spliceosomal role, PDCD7 promotes apoptosis when overexpressed and functions as a downstream target of the REST transcription factor in glioblastoma cells 2. PDCD7 is regulated by non-coding RNAs; miR-455-3p directly targets PDCD7 to suppress neuronal apoptosis in hippocampal injury models 3. Clinically, PDCD7 overexpression is significantly associated with poor prognosis in acute myeloid leukemia (AML), emerging as an independent risk factor for reduced overall survival and relapse-free survival in cytogenetically normal AML 45. Additionally, the H9N2 influenza virus polymerase acidic subunit binds PDCD7 to induce apoptosis in lung cells, suggesting PDCD7 involvement in viral-induced cell death pathways 6. PDCD7 dysregulation is implicated in diverse pathological conditions including cancer and neurological disorders 7.