SNX7 (sorting nexin 7) is a membrane-associated protein that plays crucial roles in intracellular trafficking and autophagy regulation. The protein contains both a PX domain and a BAR domain, enabling it to bind phosphoinositides including PtdIns(5)P, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 1. SNX7 functions in endocytosis regulation and multiple stages of intracellular trafficking, particularly working with SNX4 to regulate autophagosome assembly through control of ATG9A trafficking and recycling 2. In neurological contexts, SNX7 participates in a glial signaling pathway that activates caspase-8-driven IL-1β production, which induces TDO2 and affects the kynurenine pathway 3. The protein also influences amyloid-β production by directing amyloid precursor protein (APP) toward lysosomal degradation, potentially impacting Alzheimer's disease pathogenesis 4. SNX7 has emerged as a biomarker in multiple cancers, being upregulated in hepatocellular carcinoma where it correlates with poor prognosis and treatment response 5, and identified as a prognostic factor in lung adenocarcinoma 6 and glioblastoma, where it promotes tumor progression by inhibiting protective mitophagy 7.