SORBS2 is an adapter protein that assembles signaling complexes linking ABL kinases to the actin cytoskeleton 1. It regulates cytoskeletal organization through interactions with integrins and plays critical roles in multiple disease contexts. In the cardiovascular system, SORBS2 expression increases during pathological cardiac remodeling in a GATA4-dependent manner and correlates with heart failure severity 1. Cardiomyocyte-specific loss of SORBS2 exacerbates fibrotic responses through altered integrin interactions and extracellular matrix composition 1. SORBS2 also functions as a disease susceptibility locus for aortic stiffness and blood pressure regulation 2. In left ventricular noncompaction cardiomyopathy, elevated SORBS2 interacts with proteins including YWHAQ, negatively affecting cell cycle progression 3. Beyond cardiology, SORBS2 acts as a tumor suppressor in esophageal squamous cell carcinoma by binding TIMP3 mRNA in the 3' UTR, enhancing its stability and inhibiting cell proliferation and invasion 4. In familial hypercholesterolemia, SORBS2 upregulation promotes inflammation and foam cell formation through NLRP3-Caspase1 and NF-κB pathways 5. A novel SORBS2 missense variant (T189M) associates with familial Alzheimer's disease, promoting neuroinflammation and neuronal injury 6. Additionally, SORBS2 induces senescence in primary human fibroblasts and keratinocytes 7.