SOX14 is a Group B SRY-box transcription factor that functions as a sequence-specific DNA-binding protein involved in developmental regulation 1. As a member of the SOX gene family, SOX14 contains the characteristic HMG-box domain responsible for DNA binding and serves as a putative transcriptional regulator 1. The protein is expressed in developing neural tissues, including the foetal brain, spinal cord, and notably the apical ectodermal ridge of developing limb buds, suggesting important roles in nervous system and limb development 2. Human SOX14 maps to chromosome 3 and shows remarkable sequence conservation across vertebrate species, indicating functional significance 3. The SOX14 promoter contains a functional CCAAT box motif essential for gene transcription 4. While initially proposed as a candidate gene for craniofacial and limb defects associated with Blepharophimosis-ptosis-epicanthus inversus syndrome and Möbius syndrome, subsequent fine mapping excluded SOX14's involvement in these disorders 3. In hematological malignancies, SOX14 is overexpressed in approximately 10-22% of acute myeloid leukemia patients, with preliminary evidence suggesting prognostic significance 5. The ancestral synteny between SOX2 and SOX14 has been conserved for over 170 million years of mammalian evolution, underscoring the evolutionary importance of these linked genes 6.