SPATC1 (spermatogenesis and centriole associated 1) is a centrosomal protein with primary roles in spermatogenesis and male reproductive function. The gene localizes to the centrosome, the microtubule organizing center critical for cellular division and cilia formation 1. SPATC1 is upregulated during sexual maturation in males, correlating with enhanced sperm fertility 2. At the molecular level, SPATC1 is a direct transcriptional target of the BNC1/TAF7L complex, which regulates spermatogenesis-specific gene expression 3. The gene is sensitive to environmental and physiological stress; cigarette smoke exposure altered SPATC1 expression in sperm 4, and hypothalamic ghrelin signaling during metabolic stress decreased SPATC1 expression, impairing sperm quality and embryo development 5. SPATC1 is also associated with sex determination pathways, as it is regulated by lncRNAs controlling testis-dominant genes and spermatogenesis 6. Additionally, genetic variation in SPATC1 (rs60050811) shows associations with sun protection behaviors in childhood 7. Clinically, SPATC1 dysfunction may contribute to male infertility through defective spermatogenesis, while SPATC1 alterations represent potential biomarkers for reproductive health assessment.