SPICE1 (spindle and centriole associated protein 1) is a critical regulator of centriole duplication and mitotic chromosome 3. Mechanistically, SPICE1 cooperates with CEP120 and CPAP to control centriole length by localizing CEP135 to procentrioles 1. During mitosis, SPICE1 is phosphorylated by Aurora kinases at specific residues (549-855), which regulates its subcellular localization from centrioles to the spindle apparatus; dysregulation of this phosphorylation causes abnormal centriole numbers, spindle multipolarity, and chromosome 3 2. Beyond canonical mitotic functions, SPICE1 has emerged as an oncogenic driver in osteosarcoma. SPICE1 is significantly overexpressed in osteosarcoma tissues and promotes tumor cell proliferation by stabilizing fatty acid synthase (FASN) through inhibition of its ubiquitination, a process facilitated by enhanced SPICE1-USP10 interaction 3. High SPICE1 expression correlates with poor patient prognosis 3. Additionally, SPICE1 upregulation promotes keloid formation in a mouse model and represents a diagnostic biomarker and potential therapeutic target for this fibro-proliferative disorder 4. Genetic studies have identified SPICE1 variants in pediatric sarcoidosis cases, suggesting potential roles in immune-related pathways 5. These findings collectively indicate SPICE1 functions both in normal mitotic regulation and in pathological conditions including cancer and fibrotic disease.