SPNS3 is a sphingolipid transporter belonging to the Spinster (SPNS) family of major facilitator superfamily (MFS) transporters 1. As a vertebrate ortholog of Drosophila spinster, SPNS3 participates in sphingolipid transportation across cell membranes 2, with particular involvement in sphingosine-1-phosphate signaling pathways 3. The protein contains 12 transmembrane segments characteristic of MFS transporters 1. In acute myeloid leukemia (AML), elevated SPNS3 expression promotes apoptosis resistance and is associated with poor prognosis, particularly in FLT3-ITD mutant AML 43. SPNS3 expression is regulated by the AC127521.1/MIR-139/SPNS3 competing endogenous RNA axis and FLT3-ITD mutations 3. High SPNS3 expression may maintain the AML microenvironment through sphingosine-1-phosphate signaling 3. Beyond AML, SPNS3 expression is significantly reduced in APOE ε4 carriers with Alzheimer's disease risk, suggesting involvement in neurological disease pathogenesis 5. SPNS3 is downregulated in colorectal cancer cells treated with cephalosporin-based chemotherapy combinations, correlating with enhanced apoptosis 6. Genomic regions containing SPNS3 are conserved across farmed mammals and associated with behavioral traits linked to human neuropsychiatric disorders 7.