SVOPL (SVOP like) is a transmembrane transporter protein located on chromosome 7 with structural similarity to the SLC22 family of organic cation and anion transporters 1. The gene is a paralog to the synaptic vesicle protein SVOP and shares phylogenetic relationship with SLC22 family members and SV2A-C proteins 1. SVOPL exhibits parent-of-origin-specific expression patterns consistent with genomic imprinting, demonstrating maternal-only expression 2. The gene is located within a differentially methylated region (DMR) on chromosome 7 that is altered in maternal uniparental disomy and other imprinting disorders 234. Clinically, SVOPL is relevant to multiple disease contexts. Variants in SVOPL have been identified as potential novel disease candidates in cases of embryonic and perinatal lethality 5. The gene shows altered allele-specific expression during colorectal cancer tumorigenesis, with allelic switching where the predominant allele in normal tissue becomes the lowest expressed allele in tumors 6. Additionally, SVOPL disruption has been identified in carriers of balanced chromosome 7 associated with neurocognitive disabilities 7. SVOPL methylation patterns are also affected in assisted reproductive technology-conceived infants, showing hypomethylation at birth 4, and genetic variants near SVOPL associate with handedness phenotypes in genome-wide studies 8.