SPOCK3 (SPARC, cwcv and kazal like domains proteoglycan 3) is an extracellular matrix proteoglycan that functions as a regulatory component in multiple biological processes. The protein serves as a metalloendopeptidase inhibitor, specifically inhibiting the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP, which may interfere with tumor invasion 1. SPOCK3 demonstrates significant involvement in neurological processes, with genetic variants associated with adult ADHD and personality disorders 23. The protein shows region-specific accumulation in Alzheimer's disease brain tissue, particularly in the hippocampus, where it colocalizes with amyloid plaques and exhibits pronounced regional specificity compared to other brain areas 4. In cancer biology, SPOCK3 functions as a protective prognostic factor in prostate cancer, where high expression correlates with better disease-free survival and enhanced immune cell infiltration including mast cells, NK cells, and B cells 5. The protein also serves as a prognostic biomarker in colorectal cancer, with elevated expression in tumor tissues compared to normal tissues 6. Additionally, SPOCK3 expression changes in response to environmental toxin exposure, suggesting its potential role as a biomarker for chemical-induced cellular stress 7.