Based on limited published evidence, CCDC125 (coiled-coil domain containing 125) regulates cell migration and motility through modulation of RhoGTPase signaling. UniProt annotations indicate roles in GTPase activation and negative regulation of Rho protein signal transduction and cell motility. CCDC125 expression in immune tissues (thymus, spleen, bone marrow) suppresses cell motility by deregulating RhoA, Rac1, and cdc42 activity 1. In gastric cancer, CCDC125 is significantly downregulated compared to normal tissue 2, suggesting potential involvement in cancer-related cell migration processes.