SRPRB (SRP receptor subunit beta) is a component of the signal recognition particle (SRP) receptor complex that mediates protein targeting to the endoplasmic reticulum membrane 1. Its primary function involves ensuring correct targeting of nascent secretory proteins to the ER through SRP-dependent cotranslational protein targeting mechanisms. Beyond its canonical ER translocation role, SRPRB has emerged as a biomarker in multiple disease contexts. In triple-negative breast cancer, SRPRB upregulation is significantly associated with patient survival outcomes 2. Similarly, in hepatocellular carcinoma, SRPRB functions as a key component of unfolded protein response (UPR)-related prognostic signatures, where downregulation correlates with improved survival and enhanced immunotherapy sensitivity 1, 3. Notably, SRPRB expression is negatively correlated with SERP1 in pancreatic ductal adenocarcinoma, with SRPRB upregulation promoting cell apoptosis and NF-κB pathway inhibition 4. Genetically, SRPRB variants influence alcohol metabolism; the T allele of rs17376019 is associated with lower blood alcohol concentrations 5. Additionally, SRPRB appears involved in iron homeostasis pathways, being studied alongside hepcidin regulation genes 6. In preeclampsia, SRPRB participates in competing endogenous RNA networks regulated by lncRNA AGAP2-AS1 7. These diverse associations suggest SRPRB functions extend beyond canonical protein translocation to influence cellular stress responses and disease pathogenesis.