ZFAND2A is a zinc finger AN1-type protein localized to the cytoplasm, endoplasmic reticulum, and proteasome, functioning in protein binding and proteasome-mediated ubiquitin-dependent protein catabolism 1. The gene is involved in stress response pathways, serving as an NF-kappaB-regulated gene activated during copper-induced cellular stress 2. ZFAND2A exhibits temporal expression patterns in response to proteotoxic stress, with delayed induction correlating with reduced misfolded protein accumulation 3. The protein is upregulated as part of heat stress responses conserved across human and mouse systems 4 and responds to curcumin analog EF-24 treatment in leukemia cells 5. Clinically, ZFAND2A shows disease relevance in multiple pathological conditions. It is significantly upregulated in cocaine use disorder brains, suggesting involvement in addiction-related neuroplasticity 1. ZFAND2A functions as a key immunoregulatory molecule in intervertebral disc degeneration, correlating with immune cell infiltration and involved in immune-related pathways 6. In colorectal cancer, ZFAND2A demonstrates tumor-suppressive properties, with overexpression inhibiting cancer cell proliferation and migration while promoting M1 macrophage polarization 7. Lower ZFAND2A expression predicts poor prognosis, positioning it as both a prognostic biomarker and potential therapeutic target for cancer intervention.