LRRC75A-AS1 is a long non-coding RNA (lncRNA) that functions as a key regulator in multiple cellular processes, primarily through competitive endogenous RNA (ceRNA) mechanisms. The lncRNA is localized in the cytoplasm and demonstrates tissue-specific expression patterns 1. In cancer contexts, LRRC75A-AS1 exhibits complex roles: it acts as a tumor suppressor in colorectal carcinoma by inhibiting cell proliferation and migration 2, while functioning as an oncogene in breast cancer through the miR-489-3p/ARD1 axis to promote proliferation, invasion, and epithelial-mesenchymal transition (EMT) 3. In cervical cancer, LRRC75A-AS1 drives EMT by binding IGF2BP1 and inhibiting SYVN1-mediated NLRP3 ubiquitination, activating IL1β/Smad2/3 signaling 4. The lncRNA also regulates immune responses, with macrophage-enriched LRRC75A-AS1 controlling polarization and innate immune functions, including phagocytosis and cytokine secretion 5. Additionally, LRRC75A-AS1 functions in non-malignant contexts, acting as a negative regulator of vascular calcification by decreasing osteoblast-related factors 1 and mediating anti-inflammatory effects in spinal cord injury through FDFT1 regulation 6. The lncRNA consistently operates through miRNA sponging mechanisms, particularly targeting miR-199b-5p, miR-429, and miR-489-3p to modulate downstream protein expression.