SH3BGRL (SH3 domain binding glutamate rich protein like) functions as a multifunctional adapter protein with tumor suppressor activities in various cancers. The protein bridges proteins together or proteins with mRNAs and may function as a ubiquitin ligase-substrate adapter 1. SH3BGRL associates with translating cytoplasmic ribosomes, promoting specific mRNA expression through ribosomal protein interactions 12. In breast cancer, SH3BGRL promotes metastasis by enhancing STUB1 translation, leading to PFN1 degradation and activation of AKT, NF-kB, and WNT signaling pathways 1. Conversely, SH3BGRL exhibits tumor suppressor functions in hematologic malignancies, being downregulated in 62.37% of acute myeloid leukemia (AML) cases with poor prognosis 3. In AML, SH3BGRL expression correlates with positive therapeutic response and sensitizes cells to chemotherapy by promoting apoptosis 34. The protein is also suppressed by EZH2-mediated epigenetic mechanisms in lung cancer, where its overexpression inhibits cancer stem cell self-renewal and tumor progression 5. SH3BGRL expression patterns vary during zebrafish development, suggesting roles in neural system development and intestinal homeostasis 6. These findings indicate SH3BGRL has context-dependent oncogenic or tumor suppressor functions across different cancer types.