KLHL30 is a kelch-like protein that functions as a substrate adaptor for Cul3-RING ubiquitin ligase complexes, facilitating proteasome-mediated protein degradation 1. Located in the cytoplasm, KLHL30 exhibits ubiquitin-like ligase-substrate adaptor activity, suggesting a role in selective protein turnover 1. KLHL30 shows differential expression in glioblastoma multiforme compared to normal brain tissue, implicating it in gliomagenesis 1. In hepatocellular carcinoma, KLHL30 emerged as a key prognostic gene in a multi-gene model incorporating tumor stem cell content and immune infiltration; the resulting ICRP prognostic score demonstrated strong predictive accuracy (AUC 0.765 at 5 years) 2. Additionally, KLHL30 was identified as a hub gene in bone marrow mesenchymal stem cell (BMSC) differentiation networks, with differential expression patterns during both adipogenic and osteogenic lineage commitment 3. These findings suggest KLHL30 participates in cellular differentiation, cancer progression, and immune-related processes, though its specific molecular substrates and precise mechanisms remain to be elucidated.