KLHL28 is a Kelch-like protein functioning as a ubiquitin-like ligase-substrate adaptor in the Cul3-RING ubiquitin ligase complex, localizing to the cytoplasm where it mediates proteasome-dependent protein degradation. Based on limited published evidence, KLHL28 has been identified as a gene marker specifically expressed in myocardial infarction (MI), demonstrating high predictive performance for MI diagnosis and prognosis 1. However, its specific molecular mechanisms in cardiac pathology remain poorly characterized.