IPP (intracisternal A particle-promoted polypeptide) is a novel human gene encoding a 584 amino acid, 66kDa kelch family protein with actin-binding properties 1. The protein contains an N-terminal POZ protein-protein interaction domain and a C-terminal kelch repeat domain consisting of six tandem repeats, with actin-binding activity specifically mediated by the kelch repeat domain 1. IPP is mapped to chromosome 1-1p34 and exhibits complex tissue-specific expression patterns, with 1.4 and 2.2kb transcripts found exclusively in testis, while 5.0 and 7.3kb messages are expressed in ovary, placenta, small intestine, spleen, testis, and thymus 1. The gene spans more than 47kb of genomic DNA and comprises eight exons 1. Based on its structural domains and demonstrated actin-binding capacity through cosedimentation assays with glutathione S-transferase fusion proteins, IPP likely functions in organizing the actin cytoskeleton 1. However, detailed mechanistic studies of IPP's cellular functions, disease associations, and clinical significance remain limited in the provided literature, indicating the need for further research to fully characterize this kelch family member's biological roles.