SRRD (SRR1 domain containing) is a poorly characterized protein that plays a multifaceted role in cellular homeostasis and regulation. The protein functions as a key regulator of protein inclusion formation and proteostasis, with loss of SRRD resulting in aberrant intermediate filament organization and impaired aggresome assembly during proteotoxic stress 1. Through APEX biotin labeling, SRRD has been shown to reside in proximity to proteins involved in disulfide bond formation and breakage, as well as intermediate filaments, suggesting its role in regulating spatial dynamics of the intermediate filament network 1. The protein localizes to both aggresomes and unfolded proteins, and can rescue proteotoxicity in yeast models, with its N-terminal low complexity domain being sufficient for this protective effect 1. Additionally, SRRD appears to have broader implications in human health, as differential DNA methylation at the SRRD locus has been associated with neonatal morbidity risk scores in very preterm infants, particularly in relation to bronchopulmonary dysplasia 2. These findings suggest that SRRD functions as an important regulator of cytoskeletal organization and cellular proteostasis, with potential clinical significance in neurodegenerative processes and neonatal health outcomes.