PSPC1 (paraspeckle component 1) is an RNA-binding protein essential for nuclear paraspeckle assembly and functions as a multifunctional regulator of gene expression 1. The protein binds poly(A), poly(G), and poly(U) RNA sequences 2 and forms homo- and heterodimers with NONO and SFPQ, enabling cooperative RNA recognition 3. Mechanistically, PSPC1 regulates transcription through multiple pathways. It enhances RNA polymerase II engagement and activity by stabilizing transcription condensates via RNA-dependent phase separation 4. PSPC1 also cooperates with PU.1 to regulate leukemic transcription programs and acts as a regulatory subunit for the m6A demethylase ALKBH5, promoting m6A erasure on target mRNAs 5. Additionally, PSPC1 participates in pre-mRNA splicing events, working with NONO to regulate alternative splicing patterns including intron retention 6. Clinically, PSPC1 shows prominent disease relevance in acute myeloid leukemia (AML) and pancreatic ductal adenocarcinoma (PDAC). PSPC1 is aberrantly overexpressed in AML patients and is essential for maintaining leukemic characteristics; PSPC1 loss induces differentiation and suppresses leukemogenesis 7. In PDAC, elevated SKP2 expression promotes metastasis by suppressing TRIM21-mediated PSPC1 degradation 8, suggesting the SKP2/PSPC1 axis as a therapeutic target.