1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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7PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnucleusregulation of DNA-templated transcriptionprostate carcinomaglioblastoma multiformediabetes mellitusposterior cortical atrophy
Based on limited published evidence, SSX7 is an X-linked gene that may function as a transcriptional modulator through protein-binding interactions in the nucleus. SSX7 belongs to the SSX gene family, characterized as cancer-testis antigens 1. Among normal tissues, SSX7 mRNA expression is restricted to testis. In tumor cells, SSX7 was detected in only 1 of 9 melanoma cell lines tested. Unlike some SSX family members, SSX7 expression is not induced by epigenetic modifiers, suggesting alternative regulatory mechanisms 1.
1
SSX7 is a cancer-testis antigen with testis-specific expression in normal tissues; expressed in limited melanoma cell lines; not induced by DNA methylation or histone acetylation inhibitors
PMID: 12216073⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
prostate carcinomaOpen Targets
glioblastoma multiformeOpen Targets
diabetes mellitusOpen Targets
posterior cortical atrophyOpen Targets
cervical cancerOpen Targets
Hereditary breast cancerOpen Targets
hereditary breast carcinomaOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
No pathogenic variants reported on ClinVar for this gene.