STRIP1 (striatin interacting protein 1) is a structural scaffolding component of striatin-interacting phosphatase and kinase (STRIPAK) complexes, which are large multisubunit assemblies integrating diverse cellular signals 1. The human STRIPAK core structure comprises PP2AA, PP2AC, STRN3, STRIP1, and MOB4, with STRIP1 serving alongside other components to organize signal integration for Hippo pathway regulation of cell proliferation and survival 2. STRIP1 plays critical roles in cytoskeletal organization and cell morphology through its participation in STRIPAK complexes, which regulate multiple signaling pathways including Hippo, MAPK, and nuclear receptor signaling 1. Clinically, STRIP1 expression is significantly reduced in human dilated and ischemic cardiomyopathies, and functions as a negative regulator of cardiomyocyte hypertrophy by modulating MST1/MST2 kinase activities and Calcineurin/NFAT pathways 3. STRIP1 has been identified as a genetic locus positively correlated with knee osteoarthritis progression 4. STRIPAK complexes containing STRIP1 have been implicated in cardiac disease, diabetes, autism, and cerebral cavernous malformation 1, highlighting STRIP1's potential as a therapeutic target for cardiac and metabolic diseases.